FAS : The Functions of Alternative Splicing 
22-23 Jun 2020 Paris, Île-de-France (France)

The Functions of Alternative Splicing

Blind men and an elephant

 

Registration is now open
free until March 31st
closed on May 7th

Keynote Speakers

  • Introductory Keynote: J. Giudice (University of North Carolina at Chapell Hill, USA)
  • Cancer:  D. Auboeuf (ENS Lyon, France)

  • Quantitative methods: M. Vidal (Dana Farber Cancer Institute, USA)

  • Evolution: A. Urrutia (University Bath, UK)
  • Chromatin/Regulation: R. F. Luco (IHG Montpellier, France)

  • Structures and Interactions: M. Fuxreiter (U. Debrecen, Hungary)

Key dates

Deadline for Oral communication abstracts: 2020/03/20

Deadline for Poster communication abstracts: 2020/04/17

Deadline for Registration: 2020/05/07 (free until 2020/03/31) 

Presentation

Alternative splicing (AS) greatly contributes to functional diversity in multicellular eukaryotes. It augments and enriches the protein repertoire by generating multiple transcript isoforms from the same gene. In Human, AS affects almost all multi-exonic genes and its deregulation leads to diseases like cancer. From an evolutionary perspective, about 25% of the AS events common to human and mouse are also conserved in vertebrates. This supports an important role of AS in expanding the protein repertoire through evolution. 

In the last decade, deep surveys of the splicing complexity across species have become possible, thanks to the advent of high-throughput sequencing technologies like RNA-Seq, or Mass Spectrometry. However, most studies are mainly observational, and only provide insights about AS regulation. Hence, there is a need to move towards more mechanistic interpretations of the role of AS in the cell and in disease. This issue can be addressed through different angles, at the cross-talk between sequence and structure.

The goal of this meeting is to present a panorama of the current research about the function of alternative splicing. It will gather people from different backgrounds working on the subject of alternative splicing: wet-lab biologists and computational biologists from genomics to structural bioinformatics. The thematic sessions will span a wide range of points of view and emphasize some associated challenges. These include handling massive amounts of heterogeneous and sparse data, automatically identifying pertinent information in complex data representations, characterizing intrinsically disordered protein regions, predicting protein interaction partners, dating the appearance of alternative splicing events in evolution, quantifying protein isoforms in different physiopathological contexts.

Scientific Commitee

Dr. Elodie Laine (Sorbonne University)
Dr. Reini F. Luco (CNRS - IHG Montpellier)
Dr. Hugues Richard (Sorbonne University - Robert Koch Institute)

 

Sponsors

 

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